The Role of Epigenetic Modification of PAX8 in Hypersomnia

2022 Strategic Research Grant

DAVID PLANTE, MD, PHD
UNIVERSITY OF WISCONSIN-MADISON

Key Project Outcomes

The regulation of genes is fundamental to a number of biological processess and sleep disorders. This study sought to replicate prior findings that linked a specific gene and its regulation to hypersomnia. While results did not replicate these findings, the research has identified other promising candidate genes whose regulation may be highly relevant to disorders of excessive daytime sleepiness that do not have a known biological cause.