Sleep Apnea and Influence of Obesity across the Atrial Fibrillation Trajectory
2021 Bridge to Success Grant for Mid-Career/Senior Investigators
Reena Mehra, MD, MS
Cleveland Clinic Foundation
Key Project Outcome
The AASM grant has provided critical support to allow the creation of the largest data set of which we are aware of integrated genomics, metabolomics and a subset with proteomics in those with sleep disordered breathing and atrial fibrillation. Multi-omic characterization of the influence of sleep disordered breathing and associated hypoxia provides key insights to mechanisms in SDB and AF and also allows for identification of molecular endotypes associated with clinical outcomes including alterations of the cardiac substrate.