Impact of Nocturnal Hypoxemia on Glucose in High Altitude Sleep Disordered Breathing

2020 Bridge to Success Grant for Early Career Investigators

Luu Pham, MD
Johns Hopkins University

Key Project Outcomes

Studies supported by this grant contribute important knowledge regarding the impact of sleep-related hypoxemia in persons who reside at high altitude. Specifically, the nighttime period exposes highlanders to unique patterns of hypoxemia, with distinctly different impact on heart rate during sleep. An unexpected finding was the increased time in REM sleep linked to higher blood pressure during wakefulness. Additional studies are needed to understand how these nighttime stresses affect long-term cardiovascular and metabolic health.

This grant also greatly advanced Dr. Pham’s career development, and lead to his obtaining a long-term grant, which will propel him to a career as an independent scientist, focused on the role of sleep in the development of cardiovascular and metabolic diseases.

Journal Articles

AMERICAN JOURNAL OF PHYSIOLOGY

D-dimer in Marfan Syndrome: effect of obstructive sleep apnea induced blood pressure surges

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Sleep Apnea, Hypoxia Inducible Factor, and Fatty Liver: More Questions Than Answers?

CHEST

Smoothing out the Peaks and Valleys of High Altitude Sleep Apnea

FRONTIERS IN PHYSIOLOGY

Leptin Receptor Blockade Attenuates Hypertension, but Does Not Affect Ventilatory Response to Hypoxia in a Model of Polygenic Obesity

Time Domains of Hypoxia Responses and -Omics Insights

HANDBOOK OF CLINICAL NEUROLOGY

Obstructive sleep apnea

HYPERTENSION

Pharmacological and Genetic Blockage of Trpm7 in the Carotid Body Treats Obesity-Induced Hypertension

JOURNAL OF APPLIED PHYSIOLOGY

Diet-induced obesity leads to sleep fragmentation independently of the severity of sleep-disordered breathing

JOURNAL OF CLINICAL SLEEP MEDICINE

Isovolemic hemodilution in chronic mountain sickness acutely worsens nocturnal oxygenation and sleep apnea severity

NATURE OF SCIENCE AND SLEEP

Effects of Dinner Timing on Sleep Stage Distribution and EEG Power Spectrum in Healthy Volunteers

SLEEP

Combined intermittent and sustained hypoxia is a novel and deleterious cardio-metabolic phenotype

Isocapnic CO2 administration stabilizes breathing and eliminates apneas during sleep in obese mice exposed to hypoxia

Abstracts

EXPERIMENTAL BIOLOGY

Obesity-Induced Breathing Variability During Sleep Is Independent of Apneas and Sleep Fragmentation

SLEEP

Obesity-Induced Breathing Variability During Sleep Is Not Entirely Attributed to Apneas and Sleep Fragmentation