Impact of Nocturnal Hypoxemia on Glucose in High Altitude Sleep Disordered Breathing
2020 Bridge to Success Grant for Early Career Investigators
Luu Pham, MD
Johns Hopkins University
Key Project Outcomes
Studies supported by this grant contribute important knowledge regarding the impact of sleep-related hypoxemia in persons who reside at high altitude. Specifically, the nighttime period exposes highlanders to unique patterns of hypoxemia, with distinctly different impact on heart rate during sleep. An unexpected finding was the increased time in REM sleep linked to higher blood pressure during wakefulness. Additional studies are needed to understand how these nighttime stresses affect long-term cardiovascular and metabolic health.
This grant also greatly advanced Dr. Pham’s career development, and lead to his obtaining a long-term grant, which will propel him to a career as an independent scientist, focused on the role of sleep in the development of cardiovascular and metabolic diseases.
Journal Articles
AMERICAN JOURNAL OF PHYSIOLOGY
D-dimer in Marfan Syndrome: effect of obstructive sleep apnea induced blood pressure surges
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
Sleep Apnea, Hypoxia Inducible Factor, and Fatty Liver: More Questions Than Answers?
CHEST
Smoothing out the Peaks and Valleys of High Altitude Sleep Apnea
FRONTIERS IN PHYSIOLOGY
Time Domains of Hypoxia Responses and -Omics Insights
HANDBOOK OF CLINICAL NEUROLOGY
HYPERTENSION
JOURNAL OF APPLIED PHYSIOLOGY
JOURNAL OF CLINICAL SLEEP MEDICINE
NATURE OF SCIENCE AND SLEEP
Effects of Dinner Timing on Sleep Stage Distribution and EEG Power Spectrum in Healthy Volunteers
SLEEP
Combined intermittent and sustained hypoxia is a novel and deleterious cardio-metabolic phenotype
Abstracts
EXPERIMENTAL BIOLOGY
Obesity-Induced Breathing Variability During Sleep Is Independent of Apneas and Sleep Fragmentation