Identification of optimal, evidence-based definitions of apnea and hypopnea leveraging the National Sleep Research Resource

2017 Strategic Research Grant

Ali Azarbarzin, PhD and Susan Redline, MD, MPH

Brigham and Women’s Hospital

The main outcomes of this grant are: 1) the apnea/hypopneas that are accompanied by a 3% or more oxygen desaturations are consistently associated with adverse health outcomes; 2) exclusion of arousals from sleep from the AHI definition may provide alternative AHIs with stronger associations with outcomes, however, future research is needed to confirm these findings.

Journal Articles


The sleep apnea-specific hypoxic burden predicts incident heart failure.

Journal of Sleep Research

Interhemispheric sleep depth coherence predicts driving safety in sleep apnea

The Sleep Apnea–Specific Pulse-Rate Response Predicts Cardiovascular Morbidity and Mortality


Engineering in Medicine and Biology Society

Validating an algorithm for automatic scoring of Inspiratory Flow Limitation within a range of recording settings

American Journal of Respiratory and Critical Care Medicine

Post-event tachycardia combined with sleep apnea-specific hypoxic burden is a strong predictor of cardiovascular morbidity and mortality