Identification of optimal, evidence-based definitions of apnea and hypopnea leveraging the National Sleep Research Resource
2017 Strategic Research Grant
Ali Azarbarzin, PhD and Susan Redline, MD, MPH
Brigham and Women’s Hospital
The main outcomes of this grant are: 1) the apnea/hypopneas that are accompanied by a 3% or more oxygen desaturations are consistently associated with adverse health outcomes; 2) exclusion of arousals from sleep from the AHI definition may provide alternative AHIs with stronger associations with outcomes, however, future research is needed to confirm these findings.
The sleep apnea-specific hypoxic burden predicts incident heart failure.
Journal of Sleep Research
Interhemispheric sleep depth coherence predicts driving safety in sleep apnea
The Sleep Apnea–Specific Pulse-Rate Response Predicts Cardiovascular Morbidity and Mortality
Engineering in Medicine and Biology Society
Validating an algorithm for automatic scoring of Inspiratory Flow Limitation within a range of recording settings
American Journal of Respiratory and Critical Care Medicine
Post-event tachycardia combined with sleep apnea-specific hypoxic burden is a strong predictor of cardiovascular morbidity and mortality