The AASM Foundation funds high-impact projects that are aimed at improving sleep health for all. Over the past 22 years, the AASM Foundation has invested more than $19.2 million in funding career development, high-impact research, clinical training and community initiatives. These cross-cutting sleep projects range from molecular mechanisms of sleep to population sleep health.
Congratulations to the recipients of our 2021 grant cycle.
2021 Strategic Research Grant Recipients
Insomnia is common among shift workers. However, the gold standard treatment (cognitive-behavioral therapy for insomnia, CBTI) has rarely been tested among shift workers and is not optimized for their unique schedules and challenges. This study will pilot test the feasibility and acceptability of CBTI-Shift, which adapts and personalizes CBTI for shift workers. The long-term objective of this research is to improve the sleep, health and wellbeing of shift workers using an evidence-based treatment of insomnia.
Obstructive Sleep Apnea (OSA) is associated with incident cardiovascular (CV) disease, however the impact of OSA treatment on CVD events is indeterminate. Furthermore, there is a growing body of evidence suggesting OSA may be cardioprotective. Earlier studies did not discover significant effects of CPAP treatment on CV events, probably because of heterogeneity of CPAP effect in patients with varying baseline clinical characteristics resulting in the masking of treatment effects. We therefore propose a subtyping approach using machine learning to identify subgroups of patients in the ISAACC trial that may benefit or are perhaps harmed from CPAP therapy.
Insomnia is common in adolescents, yet most insomnia treatments have been developed for adults. We propose to adapt an efficacious adult treatment (Cognitive Behavioral Therapy for Insomnia; CBT-I) for adolescents. To develop this adapted protocol (Cognitive Behavioral Therapy for Insomnia in Teens; CBT-IT), we will conduct virtual groups with key stakeholders, including adolescents, parents and providers. We will then conduct a randomized controlled trial of CBT-IT to assess its efficacy in treating insomnia in adolescents.
Despite the prevalence of insomnia among socioeconomically disadvantaged adults, few insomnia interventions have targeted this group. We will conduct a randomized trial of 64 socioeconomically disadvantaged adults with insomnia to determine the efficacy of an adapted tele-Brief Behavioral of Insomnia (BBTI). We hypothesize that compared to patients randomized to an attention-control, those randomized to BBTI will have greater improvements in insomnia symptoms at three months. This project will advance insomnia treatments for socioeconomically disadvantaged adults.
This randomized controlled trial will compare the efficacy of two remote therapeutics, namely THIM (administers Intensive Sleep Retraining) and SHUT-I (online CBT-I program), against a control condition for treating Chronic Insomnia Disorder. The study will also evaluate the combination of remote therapies (THIM followed by SHUT-I) to determine whether this novel approach leads to greater benefits than either treatment alone. The trial will inform clinical decision-making about choice of therapy and build a case for health insurance-funded remote therapy options for insomnia.
Shift workers are critical to essential all 24-hour operations; however, many never adapt to the inverted sleep-wake schedule, leading to circadian misalignment and shift work disorder (SWD). One critical barrier to treating SWD has been a lack of clinically feasible approaches to quantifying circadian misalignment. To address this, we will test the use of Apple Watch in conjunction with a consumer-oriented mobile application (SHIFT) to assess and correct for circadian misalignment in night shift workers.
2021 Diversity Supplement Grant Recipients
Despite treatment benefits, obstructive sleep apnea (OSA) remains undertreated among older adults with comorbid cardiovascular disease (CVD). This project will determine the impact of untreated OSA and quantify the effect of treatment adherence on hospitalizations and 30-day readmissions among older-adult Medicare beneficiaries with pre-existing CVD. This award will provide the grantee with a mentored research and training experience that establishes her as emerging sleep researcher and advances her skills in analyzing large claims datasets.
Circadian misalignment is associated with poorer glycemic control in young adults with type 1 diabetes. The purpose is to compare three methods to analyze circadian, sleep-wake, and glucose variability characteristics. This project will prepare the candidate for a dissertation focused on the role of the circadian system in drug polyconsumption and treatment management. Her long-term goal is to become an academic researcher with a focus on methadone maintenance treatment in Brazil.